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Advanced filters: Author: Niles Lehman Clear advanced filters

  • In models of early life it has been suggested that life and evolution would be more easily achieved if RNA molecules could interact, rather than function independently; here an in vitro system is designed with several RNA fragments that can assemble into a ribozyme, showing that cooperative networks formed by these fragments outcompete self-catalytic RNA fragments.

    • Nilesh Vaidya
    • Michael L. Manapat
    • Niles Lehman
    Research
    Nature
    Volume: 491, P: 72-77

  • Directed evolution of nucleic acids and proteins in the laboratory can produce many novel phenotypes in a relatively short time frame. A significant enhancement to these techniques allows continuous evolution in special turbidostats and can speed the discovery of proteins with desirable activities.

    • Niles Lehman
    News & Views
    Nature Chemical Biology
    Volume: 7, P: 252-253

  • An RNA replicase ribozyme has long been sought by chemists interested in the origin of life. Now, a selection strategy employing a low-temperature water–ice mixture as the medium has led to discovery of a ribozyme that can catalyse polymerization of an RNA chain greater than its own length.

    • Niles Lehman
    News & Views
    Nature Chemistry
    Volume: 5, P: 987-989

  • The 'RNA World' hypothesis presupposes the existence of a catalytic RNA that can polymerize nucleotide triphosphates to replicate a template, but such chemistry has not previously been detected in natural ribozymes. Detailed investigation of the products of a bacterial self-splicing group I intron now suggest that such ribozymes indeed exist in nature.

    • Niles Lehman
    News & Views
    Nature Chemical Biology
    Volume: 5, P: 73-74

  • The RNA World concept is the idea that billions of years ago — before current life based on DNA, RNA and proteins — the primary living substance was RNA or something chemically similar. This Review highlights the challenges and solutions of this point of view, particularly for the synthesis and replication of RNA, and how various types of molecular cooperation probably had important roles.

    • Paul G. Higgs
    • Niles Lehman
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 7-17