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C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer

Obesity is linked to cancer risk in post-menopausal breast cancer. At the molecular level this is governed by cellular adaption to palmitic acid through epigenetic activation of a C/EBPB-dependent transcriptional network that drives tumor formation.

Xiao-Zheng Liu
Anastasiia Rulina
Nils Halberg
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-17
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels

PAQR4 regulates cellular ceramide synthesis and accumulation to mediate adipose tissue function, glucose homoeostasis and, thus, systemic metabolic health.

Qingzhang Zhu
Shiuhwei Chen
Philipp E. Scherer
Research03 Jul 2024
Nature Metabolism

Volume: 6, P: 1347-1366
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases

Malladi and colleagues show that inhibiting DRP1 limits mitochondrial plasticity, resulting in increased mitochondrial fusion, impaired fatty acid oxidation and reduced metastasis formation in breast cancer models.

Pravat Kumar Parida
Mauricio Marquez-Palencia
Srinivas Malladi
Research29 May 2023
Nature Cancer

Volume: 4, P: 893-907
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

The microRNA miR-126 suppresses the formation of breast cancer metastases via the suppression of several novel pro-angiogenic genes that cooperate in the recruitment of endothelial cells, leading to the formation of metastatic colonies.

Kim J. Png
Nils Halberg
Sohail F. Tavazoie
Research14 Dec 2011
Nature

Volume: 481, P: 190-194
Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival

Tavazoie and colleagues report that activation of pannexin-1 channels and the subsequent stimulation of autocrine purinergic signalling promotes the survival of disseminated cancer cells in the microvasculature of metastasis target organs.

Paul W. Furlow
Steven Zhang
Sohail F. Tavazoie
Research22 Jun 2015
Nature Cell Biology

Volume: 17, P: 943-952
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

The protein hormone adiponectin is known to have many beneficial systemic effects, including promoting cell survival, anti-inflammation and insulin sensitivity. Phil Scherer and his colleagues have found that these pleiotropic effects are mediated by a ceramidase activity associated with the two known isoforms of the adiponectin receptor.

William L Holland
Russell A Miller
Philipp E Scherer
Research26 Dec 2010
Nature Medicine

Volume: 17, P: 55-63
N⁶-methyladenosine marks primary microRNAs for processing

The addition of the N⁶-methyladenosine (m⁶A) mark to primary microRNAs by METTL3 in mammalian cells is found to promote the recognition of these microRNA precursors by DGCR8, a component of the microprocessor complex.

Claudio R. Alarcón
Hyeseung Lee
Sohail F. Tavazoie
Research18 Mar 2015
Nature

Volume: 519, P: 482-485

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C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer

PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels

Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

N6-methyladenosine marks primary microRNAs for processing

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N⁶-methyladenosine marks primary microRNAs for processing