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Showing 1–6 of 6 results
Advanced filters: Author: Nima Mosammaparast Clear advanced filters

  • A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

    • Joshua R. Brickner
    • Jennifer M. Soll
    • Nima Mosammaparast
    Research
    Nature
    Volume: 551, P: 389-393

  • Replication stress induces STING-TRPV2 dissociation to promote Ca2+ release from the ER for fork protection; however, the precise mechanism remains unclear. Here, the authors identify TCAF1 as a fork protection factor that facilitates STING-TRPV2 dissociation, thereby enabling Ca2+ release.

    • Lingzhen Kong
    • Chen Cheng
    • Zhongsheng You
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Dbr1 exhibits debranching specificity and effect on splicing. Here the authors combine co-immunoprecipitation, RNA binding and lariat analysis and suggest a role for Dbr1 interactor AQR in intron recycling. Dbr1 depletion leads to increased dwell time of spliceosome on excised lariats.

    • Luke Buerer
    • Nathaniel E. Clark
    • William G. Fairbrother
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • SOX2 is required for the maintenance of glioblastoma stem cells (GSCs). Here the authors identify that the RING family E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a non-canonical ligase-independent manner and thus, increases the tumorigenicity of GSCs.

    • Tatenda Mahlokozera
    • Bhuvic Patel
    • Albert H. Kim
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • BRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependent mechanism of rescue following the withdrawal of genotoxic agent.

    • Delphine Lemaçon
    • Jessica Jackson
    • Alessandro Vindigni
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12