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Showing 1–3 of 3 results

Advanced filters: Author: Nimrod Rappoport Clear advanced filters

Single cell Hi-C identifies plastic chromosome conformations underlying the gastrulation enhancer landscape

Here the authors use single-cell Hi-C to investigate chromosome conformation in post-gastrulation mouse embryos. They find a distinct genome organization in primitive erythrocytes and conformations matching the mesodermal and ectodermal lineages.

Nimrod Rappoport
Elad Chomsky
Amos Tanay
ResearchOpen Access29 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Plasma proteomics links brain and immune system aging with healthspan and longevity

In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity.

Hamilton Se-Hwee Oh
Yann Le Guen
Tony Wyss-Coray
ResearchOpen Access09 Jul 2025
Nature Medicine

Volume: 31, P: 2703-2711
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and rejuvenation associated with neural stem cells.

Eric D. Sun
Olivia Y. Zhou
Anne Brunet
ResearchOpen Access18 Dec 2024
Nature

Volume: 638, P: 160-171