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Showing 1–4 of 4 results
Advanced filters: Author: Nino Devidze Clear advanced filters

  • DNA repair deficits have been suggested to play a role in Alzheimer’s pathology. Here, the authors report reduced levels of the DNA repair factor BRCA1 in patient brains, and provide evidence that loss of BRCA1 in the dentate gyrus leads to spatial learning and memory deficits in mice.

    • Elsa Suberbielle
    • Biljana Djukic
    • Lennart Mucke
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14

  • It is shown that amyloid-β oligomers interact with the receptor tyrosine kinase EphB2 and trigger its degradation. EphB2 regulates NMDA-type glutamate receptors and its depletion in normal mice reduces NMDA receptor currents and impairs long-term potentiation, both of which are important for memory formation. Increasing EphB2 levels in a mouse model of Alzheimer's disease improves memory.

    • Moustapha Cissé
    • Brian Halabisky
    • Lennart Mucke
    Research
    Nature
    Volume: 469, P: 47-52

  • The authors show that astrocytes produce high levels of the adenosine receptor A2A in Alzheimer brains. Reducing the levels of astrocytic A2A boosted memory in young and aging mice and mouse models of Alzheimer disease, whereas activating a related molecular pathway impaired memory. Thus, astrocytes regulate memory and abnormal receptor activity in these cells may contribute to memory disorders.

    • Anna G Orr
    • Edward C Hsiao
    • Lennart Mucke
    Research
    Nature Neuroscience
    Volume: 18, P: 423-434

  • In this study, the authors show that neuronal activity, induced by natural exploration, exposure to visual stimuli or optogenetic probe–mediated stimulation, can induce double-stranded DNA breaks (DSBs) in neurons. The numbers of these DSBs were aggravated in the presence of amyloid precursor protein and depended on extrasynaptic NMDAR activity.

    • Elsa Suberbielle
    • Pascal E Sanchez
    • Lennart Mucke
    Research
    Nature Neuroscience
    Volume: 16, P: 613-621