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Showing 1–3 of 3 results
Advanced filters: Author: Nir Eynon Clear advanced filters

  • Ying, Paulson and collagues have developed an open-source framework, Biolearn, to harmonize and systematically evaluate 39 aging biomarkers across diverse populations, enabling standardized validation and facilitating development of robust aging biomarkers.

    • Kejun Ying
    • Seth Paulson
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 5, P: 2323-2339

  • In this Review, the authors give an overview of age-related changes to the methylation landscape and the statistical tools used to quantify them. They also discuss the evidence for longevity strategies that aim to counter these changes, and the candidate mechanistic causes of epigenetic ageing.

    • Kirsten Seale
    • Steve Horvath
    • Sarah Voisin
    Reviews
    Nature Reviews Genetics
    Volume: 23, P: 585-605

  • Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduction.

    • Sara M. Willems
    • Daniel J. Wright
    • Robert A. Scott
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12