Mycobacterium tuberculosis induces a cyclic AMP (cAMP) burst within infected macrophages that influences cell signalling, but the underlying mechanism for this increase in cAMP remains unclear. It is now shown that it is produced by a bacterial adenylate cyclase that facilitates delivery of bacterial-derived cAMP into the macrophage cytoplasm, presumably enhancing virulence through the activation of downstream signalling pathways.
- Nisheeth Agarwal
- Gyanu Lamichhane
- William R. Bishai
