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Showing 1–3 of 3 results
Advanced filters: Author: Nishita Parnandi Clear advanced filters

  • EXO1 performs multiple roles in DNA replication and DNA damage repair (DDR), but its role in DDR-deficient cancers remains unclear. Here, the authors find EXO1 loss as synthetic lethal with many DDR genes involved in various cancers, including genes from Fanconi Anaemia pathway, BRCA1-A complex, and spliceosome factor ZRSR2; such interactions represent potential clinical targets.

    • Marija Maric
    • Sandra Segura-Bayona
    • Simon J. Boulton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Structural and functional dissection of the TIRR–53BP1 complex shows that TIRR acts as a regulatory switch that blocks 53BP1 binding to chromatin to direct DNA repair, and it releases 53BP1 in response to DNA damage by binding RNA.

    • Maria Victoria Botuyan
    • Gaofeng Cui
    • Georges Mer
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 591-600