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Showing 1–3 of 3 results
Advanced filters: Author: Nishma Gupta Clear advanced filters

  • TEAD transcription factors are critical effectors and druggable sites of the Hippo pathway in cancer, however, the development of small molecule inhibitors and degraders remains underexplored. Here, the authors identify and characterize bifunctional IAP-based degraders targeting TEAD1 via a lipid pocket and recruit different members of the inhibitor of apoptosis proteins (IAPs) family, offering a comprehensive toolkit for structural, biophysical and cellular profiling.

    • Nishma Gupta
    • Nicole Trainor
    • Michael J. Roy
    ResearchOpen Access
    Communications Chemistry
    P: 1-23

  • Animals that receive an inhibitor of an antiviral cell-death response called necroptosis are less likely to die of influenza even at a late stage of infection. This has implications for the development of therapies for respiratory diseases.

    • Nishma Gupta
    • John Silke
    News & Views
    Nature
    Volume: 628, P: 726-727