Mapping binding sites using photoaffinity labelling (PAL) is highly valuable but challenging for probe and drug discovery campaigns. Now a chemoproteomic approach has been developed that incorporates cleavable silyl ether linkages into PAL probes to pinpoint and quantify the precise sites where small molecules engage protein binding partners.
- Chau Ngo
- Sho Takechi
- Keriann M. Backus
