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Showing 1–3 of 3 results
Advanced filters: Author: Nitya S. Ramadoss Clear advanced filters

  • The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.

    • Jae-Seung Moon
    • Shady Younis
    • William H. Robinson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • B cells can assume protective or pathogenic roles in immune-mediated diseases (IMDs). Analysis of the B cell receptor (BCR) repertoires in six IMDs provides insights into the diversity of B cell repertoires across diseases as well as into potential pathological mechanisms and the effects of different treatments.

    • Nitya S. Ramadoss
    • William H. Robinson
    News & Views
    Nature Reviews Rheumatology
    Volume: 16, P: 7-8

  • Lanz and colleagues show that the first dose of the BNT162b2 mRNA vaccine against SARS-CoV-2 activates a non-neutralizing recall response predominantly targeting the S2 subunit of the spike protein, while the second dose boosts neutralizing antibodies specific for the receptor binding domain of the spike protein.

    • R. Camille Brewer
    • Nitya S. Ramadoss
    • Tobias V. Lanz
    Research
    Nature Immunology
    Volume: 23, P: 33-39