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Showing 1–2 of 2 results
Advanced filters: Author: Noah Lampl Clear advanced filters

  • How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thiodG) targets telomerase to inhibit telomere maintenance in cancer cells and tumors was unclear. Here, the authors show that telomere length and telomerase status determine 6-thio-dG sensitivity and uncover the molecular mechanism by which 6-thio-dG selectively inhibits telomerase synthesis of telomeric DNA.

    • Samantha L. Sanford
    • Mareike Badstübner
    • Patricia L. Opresko
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • Telomere length is tightly controlled in normal cellular function and the human population. Here, the authors reveal that telomere synthesis is bidirectionally constrained by cellular nucleotide pools, in a manner which may be therapeutically manipulated.

    • William Mannherz
    • Andrew Crompton
    • Suneet Agarwal
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14