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Bidirectional linkage of DNA barcodes for the multiplexed mapping of higher-order protein interactions in cells

A method leveraging antibodies conjugated with barcoded DNA strands to linearize closely spaced interactions from individual 3D protein complexes allows for the mapping of pairwise and higher-order protein interactions within cells.

Yu Liu
Noah R. Sundah
Huilin Shao
Research19 Jun 2024
Nature Biomedical Engineering

Volume: 8, P: 909-923
Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers

Conventional magnetic biosensing technologies have limited ability to detect magnetic field dimensionality. Here, the authors develop a platform which uses DNA hydrogels to spatially engineer a 3D magnetic response and demonstrate its use in the direct and programmable detection of RNA and protein biomarkers.

Yuan Chen
Li Zhang
Huilin Shao
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution

Barcodes based on tetrahedral DNA nanostructures enable the multiplexed profiling of the subcellular expression and distribution of proteins in cells from patient samples.

Noah R. Sundah
Nicholas R. Y. Ho
Huilin Shao
Research08 Jul 2019
Nature Biomedical Engineering

Volume: 3, P: 684-694
Visual and modular detection of pathogen nucleic acids with enzyme–DNA molecular complexes

Rapid, visual detection of pathogens is important for point-of-care diagnostics. Here the authors present enVision, which uses enzyme-DNA complexes to detect pathogen nucleic acids and provide a rapid, smartphone compatible readout.

Nicholas R. Y. Ho
Geok Soon Lim
Huilin Shao
ResearchOpen Access13 Aug 2018
Nature Communications

Volume: 9, P: 1-11
Analytical device miniaturization for the detection of circulating biomarkers

Circulating biomarkers can be detected and analysed in the form of liquid biopsies to improve disease diagnosis and monitoring. This Review discusses the integration of specific assay designs in miniaturized device platforms for the detection of circulating biomarkers, including whole cells, extracellular vesicles and cell-free factors.

Auginia Natalia
Li Zhang
Huilin Shao
Reviews31 Mar 2023
Nature Reviews Bioengineering

Volume: 1, P: 481-498

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Bidirectional linkage of DNA barcodes for the multiplexed mapping of higher-order protein interactions in cells

Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers

Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution

Visual and modular detection of pathogen nucleic acids with enzyme–DNA molecular complexes

Analytical device miniaturization for the detection of circulating biomarkers

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