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Showing 1–17 of 17 results
Advanced filters: Author: Noam Stern-Ginossar Clear advanced filters

  • HCMV infection can become productive or latent. Here the authors show that variations in the number of incoming viral particles across cell types is a key factor of this decision, identifying entry efficiency as a key regulator of latency.

    • Yaarit Kitsberg
    • Aharon Nachshon
    • Michal Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • A high-resolution map of coding regions in the SARS-CoV-2 genome enables the identification of 23 unannotated open reading frames and quantification of the expression of canonical viral open reading frames.

    • Yaara Finkel
    • Orel Mizrahi
    • Noam Stern-Ginossar
    Research
    Nature
    Volume: 589, P: 125-130

  • The RNA modification N6-methyladenosine (m6A) plays an essential role in the regulation of immunity. Here, Shulman and Stern-Ginossar review the roles of m6A in controlling immune recognition, activation of innate and adaptive immune responses, and cell fate decisions.

    • Ziv Shulman
    • Noam Stern-Ginossar
    Reviews
    Nature Immunology
    Volume: 21, P: 501-512

  • In the virus-encoded CRISPR-based direct readout system, single-guide RNA libraries are expressed directly from the genomes of viruses so that single-guide RNA abundance at distinct stages of the viral infection cycle provides direct and quantitative readout of gene-perturbation effects on viral propagation.

    • Anna Lilja
    • Yaara Finkel
    • Noam Stern-Ginossar
    Protocols
    Nature Protocols
    P: 1-37

  • A genetic screen that expresses single guide RNA libraries targeting host genes in the human cytomegalovirus genome enables identification of host factors and provides insights into their roles during the viral replication cycle.

    • Yaara Finkel
    • Aharon Nachshon
    • Noam Stern-Ginossar
    Research
    Nature
    Volume: 630, P: 712-719

  • Temporal single-cell RNA sequencing analysis of viral and host transcriptional responses during human cytomegalovirus infection of macrophages and monocytes reveals molecular features influencing distinct infection courses and suggests additional latency reservoirs.

    • Michal Schwartz
    • Miri Shnayder
    • Noam Stern-Ginossar
    Research
    Nature Microbiology
    Volume: 8, P: 455-468

  • RNA sequencing, ribosome profiling and metabolic labelling of newly synthesized RNA reveal the strategy used by SARS-CoV-2 to shut off cellular protein synthesis in the host and allow the translation of viral transcripts.

    • Yaara Finkel
    • Avi Gluck
    • Noam Stern-Ginossar
    Research
    Nature
    Volume: 594, P: 240-245

  • Natural killer cells infiltrate the pancreas during type 1 diabetes. Mandelboim and co-workers find that the natural killer receptor NKp46 recognizes ligands on pancreatic beta cells and is essential for full diabetes development.

    • Chamutal Gur
    • Angel Porgador
    • Ofer Mandelboim
    Research
    Nature Immunology
    Volume: 11, P: 121-128

  • Here, Israeli and Finkel et al. perform genome-wide CRISPR knockout screens to identify host factors required for the infection with SARS-CoV-2 and two additionally variants of concern, Alpha and Beta, unveiling shared and differential host pathways required by the variants, and demonstrate GATA6 is critical for SARS-CoV-2 viral entry through modulation of ACE2 expression.

    • Ma’ayan Israeli
    • Yaara Finkel
    • Adi Bercovich-Kinori
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Tryptophan depletion in melanoma cells after prolonged treatment with interferon-γ (IFNγ) results in ribosomal frameshifting and the production of aberrant peptides that can be presented to T cells and induce an immune response.

    • Osnat Bartok
    • Abhijeet Pataskar
    • Reuven Agami
    Research
    Nature
    Volume: 590, P: 332-337

  • The human genome contains thousands of long noncoding RNAs which have been preserved by evolution, through their functions are poorly described. Here the authors show that NORAD binds the Pumilo homologues PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.

    • Ailone Tichon
    • Noa Gil
    • Igor Ulitsky
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes, often leading to stabilization of the RNA duplex.

    • Oz Solomon
    • Ayelet Di Segni
    • Gidi Rechavi
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Transcriptome-wide mapping of N1-methyladenosine (m1A) at single-nucleotide resolution reveals m1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.

    • Modi Safra
    • Aldema Sas-Chen
    • Schraga Schwartz
    Research
    Nature
    Volume: 551, P: 251-255