Myosin X is involved in cytoskeletal processes including the extension of filopodia. It is now found that the tail of this myosin can inhibit motor activity in a manner that is antagonized by binding of PIP3, which also promotes dimer formation. Interfering with PIP3 binding affects myosin X translocation in vivo, suggesting that lipids regulate the activity of this motor.
- Nobuhisa Umeki
- Hyun Suk Jung
- Mitsuo Ikebe
