Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Nobuyasu Koga Clear advanced filters

  • Here authors developed a computational method to design complicated all-α structures using typical helix–loop–helix motifs and canonical α-helices, and demonstrated the ability to create complicated all-α proteins.

    • Koya Sakuma
    • Naohiro Kobayashi
    • Nobuyasu Koga
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 275-282

  • Here the authors carry out a systematic de novo protein design exploration of novel αβ-folds predicted under a defined set of rules for β-sheet topology, in an effort to find out the extent to which all possible αβ-folds are already sampled in nature.

    • Shintaro Minami
    • Naohiro Kobayashi
    • Nobuyasu Koga
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1132-1140

  • Rules that allow the design of strongly funnelled protein folding energy landscapes by relating secondary structure patterns to protein tertiary motifs are used to produce ideal protein structures stabilized by completely consistent local and non-local interactions.

    • Nobuyasu Koga
    • Rie Tatsumi-Koga
    • David Baker
    Research
    Nature
    Volume: 491, P: 222-227

  • Allostery produces concerted functions of protein complexes by orchestrating the cooperative work between the constituent subunits. By restoring functions of pseudo-active sites that have been lost through evolution, allosteric sites have now been designed into a rotary molecular motor, V1-ATPase, resulting in its rotation being boosted allosterically.

    • Takahiro Kosugi
    • Tatsuya Iida
    • Nobuyasu Koga
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1591-1598

  • Protein-based hydrogels are of great interest for many biomedical applications. Here, the authors demonstrate the use of mechanical labile proteins to initiate large-scale forced unfolding in order to engineer the mechanical properties of protein-based biomaterials.

    • Jie Fang
    • Alexander Mehlich
    • Hongbin Li
    Research
    Nature Communications
    Volume: 4, P: 1-10

  • Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here the authors show that actin flow can orient cell surface integrins during leukocyte migration, suggesting integrin activation by cytoskeletal force.

    • Pontus Nordenfelt
    • Travis I. Moore
    • Timothy A. Springer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16