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Showing 1–5 of 5 results
Advanced filters: Author: Nora Rauch Clear advanced filters

  • Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

    • Nora I. Strom
    • Zachary F. Gerring
    • Manuel Mattheisen
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1389-1401

  • Rauch et al. show that loss-of-function mutations in the epigenetic regulator Dnmt3a lead to accelerated atherosclerosis, as previously shown for Tet2, and that loss of either gene leads to similar changes in atheroma composition, with the emergence of a distinct population of chemokine-enriched, resident-like macrophages infiltrating the adventitia, as revealed by single-cell transcriptomics and spatial proteomic analyses.

    • Philipp J. Rauch
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 805-818

  • An approach called cell state transition assessment and regulation uses diverse multiomics data to map cell states, model their transitions, and understand the signalling networks that control them.

    • Oleksii S. Rukhlenko
    • Melinda Halasz
    • Boris N. Kholodenko
    Research
    Nature
    Volume: 609, P: 975-985

  • Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutation

    • Susan A. Kennedy
    • Mohamed-Ali Jarboui
    • Walter Kolch
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14