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Showing 1–17 of 17 results
Advanced filters: Author: Noushin Niknafs Clear advanced filters

  • In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research of tumour evolution.

    • Noushin Niknafs
    • Yi Zhong
    • Rachel Karchin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • As presented at the 2025 World Conference on Lung Cancer, in a multiarm phase 2 trial, perioperative immunotherapy was safe and feasible in patients with resectable diffuse pleural mesothelioma, with exploratory data suggesting that ctDNA kinetics could be informative of tumor regression and post-treatment survival.

    • Joshua E. Reuss
    • Paul K. Lee
    • Patrick M. Forde
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 4097-4108

  • Huang et al. analyzed serial samples from participants with metastatic non-small cell lung cancer treated with radiotherapy followed by immunotherapy and report improved clinical outcomes and enhanced antitumor responses in immunologically cold tumors.

    • Justin Huang
    • Willemijn S. M. E. Theelen
    • Valsamo Anagnostou
    ResearchOpen Access
    Nature Cancer
    Volume: 6, P: 1676-1692

  • Cell free DNA fragmentation is a promising biomarker for disease, but its epigenetic regulation is incompletely understood. Here, the authors investigated the effects of DNA methylation in the production of cfDNA fragmentation, and corelate these changes with gene expression in human cancer.

    • Michaël Noë
    • Dimitrios Mathios
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.

    • Alicia M. Braxton
    • Ashley L. Kiemen
    • Laura D. Wood
    Research
    Nature
    Volume: 629, P: 679-687

  • Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.

    • Michaël Noë
    • Noushin Niknafs
    • Laura D. Wood
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • In the first stage of the BR.36 adaptive trial in patients with non-small cell lung cancer receiving anti-PD1 immunnotherapy, the primary endpoint of concordance between circulating tumor DNA (ctDNA) molecular response and RECIST response was met. The results will inform the second, ctDNA-directed stage.

    • Valsamo Anagnostou
    • Cheryl Ho
    • Janet Dancey
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2559-2569

  • This Review summarizes current and emerging liquid biopsy methods, together with their clinical validity and utility, and highlights opportunities to support their implementation throughout the cancer care continuum.

    • Blair V. Landon
    • Akshaya V. Annapragada
    • Valsamo Anagnostou
    Reviews
    Nature Medicine
    Volume: 31, P: 4006-4021

  • Genomic analyses in large cohorts of patients with cancer identify a new measure of tumor mutational burden, based on genomic regions that are unlikely to undergo loss, that is associated with therapeutic response to immunotherapy.

    • Noushin Niknafs
    • Archana Balan
    • Valsamo Anagnostou
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 440-449

  • In a phase 2 trial, the combination of chemotherapy with durvalumab, an anti-PD-L1 antibody, exhibited promising clinical activity in patients with previously untreated, unresectable mesothelioma, with additional analyses providing insights into genomic and immunologic features potentially associated with response.

    • Patrick M. Forde
    • Valsamo Anagnostou
    • Suresh S. Ramalingam
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 1910-1920

  • DNA from tumour cells can be detected in the blood of cancer patients. Here, the authors show that cell free DNA fragmentation patterns can identify lung cancer patients and when this information is further interrogated it can be used to predict lung cancer histological subtype.

    • Dimitrios Mathios
    • Jakob Sidenius Johansen
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube.

    • S. Intidhar Labidi-Galy
    • Eniko Papp
    • Victor E. Velculescu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Analyses of fragmentation patterns of cell-free DNA in the blood of patients with cancer and healthy individuals using a machine learning algorithm provide a proof-of principle approach for the early detection and screening of human cancer.

    • Stephen Cristiano
    • Alessandro Leal
    • Victor E. Velculescu
    Research
    Nature
    Volume: 570, P: 385-389