Histone gene transcription is downregulated after DNA synthesis is completed, but how cells terminate histone gene transcription has been unknown. A new study uncovers that phosphorylation of histone H2B at Tyr37 by WEE1 kinase leads to a coordinated transcriptional repression of replication-dependent core histone genes in the late S/G2 phase in yeast and mammalian cells.
- Kiran Mahajan
- Bin Fang
- Nupam P Mahajan
