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Advanced filters: Author: Nurcin Liman Clear advanced filters

  • Clonal deletion is an important mechanism for the elimination of autoreactive T cells, however, negative selection of thymocytes is imperfect. Here authors show that MHC-II-restricted thymocytes avoid negative selection via downregulation of the integrin CD103, altering intra-thymic trafficking and distribution in a way that favours their survival.

    • Nurcin Liman
    • Can Li
    • Jung-Hyun Park
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16