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Showing 1–50 of 57 results

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Cold atmospheric plasma treatment enhances recombinant model protein production in yeast Pichia pastoris

Zeinab Kabarkouhi
Sareh Arjmand
Babak Shokri
ResearchOpen Access26 Apr 2023
Scientific Reports

Volume: 13, P: 1-14
Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells

Claudia R. Arbeitman
Gabriela Auge
Alicia M. Zelada
ResearchOpen Access11 Dec 2020
Scientific Reports

Volume: 10, P: 1-18
Natural variation in light sensitivity of Arabidopsis

Julin N. Maloof
Justin O. Borevitz
Joanne Chory
Research26 Nov 2001
Nature Genetics

Volume: 29, P: 441-446
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer

The PSA (KLK3) genetic variant rs17632542 is associated with reduced prostate cancer risk and lower serum PSA levels, although the underlying reasons are unclear. Here, the authors show that this PSA variant reduced proteolytic activity and leads to smaller tumours, but also increases invasion and bone metastasis, indicating its dual risk association depending on tumour context; the variant is associated with both lower risk and poor clinical outcomes.

Srilakshmi Srinivasan
Thomas Kryza
Jyotsna Batra
ResearchOpen Access06 Nov 2024
Nature Communications

Volume: 15, P: 1-21
The effect of non-thermal atmospheric plasma on the production and activity of recombinant phytase enzyme

Mahsa Farasat
Sareh Arjmand
Hamid Ghomi
ResearchOpen Access09 Nov 2018
Scientific Reports

Volume: 8, P: 1-12
Oomycetes manipulate plant innate immunity through galacturonide oxidases

The oomycete Phytophthora infestans is a damaging crop pathogen. Here, the authors show that a group of P. infestans secreted enzymes play roles in penetration and colonization of host plants by oxidising fragments of the polysaccharide pectin in the plant cell wall.

Lydia R. J. Welsh
Anna O. Avrova
Federico Sabbadin
ResearchOpen Access20 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Biosynthetic potential of the global ocean microbiome

Global ocean microbiome survey reveals the bacterial family ‘Candidatus Eudoremicrobiaceae’, which includes some of the most biosynthetically diverse microorganisms in the ocean environment.

Lucas Paoli
Hans-Joachim Ruscheweyh
Shinichi Sunagawa
ResearchOpen Access22 Jun 2022
Nature

Volume: 607, P: 111-118
Covalent coupling of Spike’s receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2

Paula M. Berguer
Matías Blaustein
Alicia M. Zelada
ResearchOpen Access13 Jan 2022
Scientific Reports

Volume: 12, P: 1-16
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

Two side-by-side papers report that the transcription elongation factor ELOF1 drives transcription-coupled repair and prevents replication stress.

Yana van der Weegen
Klaas de Lint
Martijn S. Luijsterburg
Research09 Jun 2021
Nature Cell Biology

Volume: 23, P: 595-607
Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Here, Lopaticki et al. show that Plasmodium falciparum expresses a Dpy19 C-mannosyltransferase in the endoplasmic reticulum that glycosylates TSR domains. Functional characterization shows that PfDpy19 plays a critical role in transmission through mosquitoes as PfDpy19-deficiency abolishes C-glycosylation and destabilizes proteins relevant for gametogenesis and oocyst formation.

Sash Lopaticki
Robyn McConville
Justin A. Boddey
ResearchOpen Access29 Jul 2022
Nature Communications

Volume: 13, P: 1-18
p53 modulation of TFIIH–associated nucleotide excision repair activity

X.W. Wang
H. Yeh
C.C. Harris
Research01 Jun 1995
Nature Genetics

Volume: 10, P: 188-195
Evolving stability and pH-dependent activity of the high redox potential Botrytis aclada laccase for enzymatic fuel cells

Stefan Scheiblbrandner
Erik Breslmayr
Roman Kittl
ResearchOpen Access20 Oct 2017
Scientific Reports

Volume: 7, P: 1-13
Structural mechanism of plant aquaporin gating

Susanna Törnroth-Horsefield
Yi Wang
Per Kjellbom
Research07 Dec 2005
Nature

Volume: 439, P: 688-694
Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

Carminic acid is a widely applied red colorant that is still harvested from insects because its biosynthesis is not fully understood. Here, the authors identify and characterize a membrane-bound C-glucosyltransferase catalyzing the final step during carminic acid biosynthesis.

Rubini Kannangara
Lina Siukstaite
Birger Lindberg Møller
ResearchOpen Access07 Dec 2017
Nature Communications

Volume: 8, P: 1-12
Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization

Quantifying the effect of mutations on binding free energy is important to understand protein-protein interaction (PPI). Here the authors develop a method based on yeast display and next-generation sequencing to generate quantitative binding landscapes for any PPI regardless of their Kd value.

Michael Heyne
Niv Papo
Julia M. Shifman
ResearchOpen Access15 Jan 2020
Nature Communications

Volume: 11, P: 1-7
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vertebrate hosts.

Sash Lopaticki
Annie S. P. Yang
Justin A. Boddey
ResearchOpen Access15 Sept 2017
Nature Communications

Volume: 8, P: 1-10
Newcastle disease virus mRNA lacks 2′-O-methylated nucleotides

RICHARD J. COLONNO
HENRY O. STONE
Research01 Jun 1976
Nature

Volume: 261, P: 611-614
Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains

Some isolates of the emerging fungal pathogen Candida auris can form cellular aggregates or filaments. Here, Santana and O’Meara use Agrobacterium-mediated transformation and a CRISPR-Cas9 system to identify several genes that regulate C. auris morphogenesis.

Darian J. Santana
Teresa R. O’Meara
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-13
Functional characterization of a lytic polysaccharide monooxygenase from Schizophyllum commune that degrades non-crystalline substrates

Heidi Østby
Idd A. Christensen
Vincent G. H. Eijsink
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Humus Decomposition in East African Soils

H. F. BIRCH
M. T. FRIEND
Research01 Sept 1956
Nature

Volume: 178, P: 500-501
Deciphering the molecular specificity of phenolic compounds as inhibitors or glycosyl acceptors of β-fructofuranosidase from Xanthophyllomyces dendrorhous

Mercedes Ramirez-Escudero
Noa Miguez
Julia Sanz-Aparicio
ResearchOpen Access25 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities

Johara Boldrini-França
Ernesto Lopes Pinheiro-Junior
Jan Tytgat
ResearchOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins

Ivan Sugrue
Carolin Ade
R. Paul Ross
ResearchOpen Access22 Jul 2025
npj Antimicrobials and Resistance

Volume: 3, P: 1-12
Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy

TLR4 agonists have been proposed as immunotherapeutics in cancer. Here, the authors show the TLR4-dependent adjuvant effect of FimH, an E. coli adhesin, in promoting dendritic cell mediated-T cell activation and response to immune checkpoint blockade in preclinical cancer models.

Wei Zhang
Li Xu
Jun-O Jin
ResearchOpen Access04 Mar 2020
Nature Communications

Volume: 11, P: 1-14
Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

Hongzhong Lu
Weiqiang Cao
Ju Chu
ResearchOpen Access26 Sept 2018
Scientific Reports

Volume: 8, P: 1-15
Neocortical excitation/inhibition balance in information processing and social dysfunction

Ofer Yizhar
Lief E. Fenno
Karl Deisseroth
Research27 Jul 2011
Nature

Volume: 477, P: 171-178
The antifungal plant defensin AtPDF2.3 from Arabidopsis thaliana blocks potassium channels

Kim Vriens
Steve Peigneur
Karin Thevissen
ResearchOpen Access30 Aug 2016
Scientific Reports

Volume: 6, P: 1-13
The plant cell-wall enzyme AtXTH3 catalyses covalent cross-linking between cellulose and cello-oligosaccharide

Naoki Shinohara
Naoki Sunagawa
Kazuhiko Nishitani
ResearchOpen Access26 Apr 2017
Scientific Reports

Volume: 7, P: 1-10
In vitro nanobody discovery for integral membrane protein targets

Rupak Doshi
Beverly R. Chen
Geoffrey Chang
ResearchOpen Access24 Oct 2014
Scientific Reports

Volume: 4, P: 1-8
Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor

Alison M. Motley
Ewald H. Hettema
Ben Distel
Research01 Apr 1997
Nature Genetics

Volume: 15, P: 377-380
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

Ubiquitin-dependent degradation of Cdc20 by the APC/C ligase is a conserved mechanism essential for maintaining the spindle assembly checkpoint activated by unattached chromosomes.

Jakob Nilsson
Mona Yekezare
Jonathon Pines
Research09 Nov 2008
Nature Cell Biology

Volume: 10, P: 1411-1420
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

Proteomics analysis, machine learning, and crystal structures reveal the substrate specificity of cysteine cathepsins.

Livija Tušar
Jure Loboda
Dušan Turk
ResearchOpen Access24 Apr 2023
Communications Biology

Volume: 6, P: 1-15
Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors

The membrane plays a key role in the interaction of non-conventional neurotoxins with the nicotinic receptors.

Zakhar O. Shenkarev
Yuri M. Chesnokov
Ekaterina N. Lyukmanova
ResearchOpen Access07 Dec 2022
Communications Biology

Volume: 5, P: 1-15
Sterile protection against relapsing malaria with a single-shot vaccine

Erica M. Pasini
Annemarie Voorberg van der Wel
Clemens H. M. Kocken
ResearchOpen Access27 Oct 2022
npj Vaccines

Volume: 7, P: 1-7
Energy expenditure and nutritional adequacy of rehabilitation paraplegics with asymptomatic bacteriuria and pressure sores

R Aquilani
F Boschi
O Pastoris
Research20 Aug 2001
Spinal Cord

Volume: 39, P: 437-441
A general protocol for the crystallization of membrane proteins for X-ray structural investigation

Zachary E R Newby
Joseph D O'Connell III
Robert M Stroud
Protocols09 Apr 2009
Nature Protocols

Volume: 4, P: 619-637
Protein-based organelles in bacteria: carboxysomes and related microcompartments

Bacterial microcompartments consist of a protein shell that encapsulates enzymes to form an 'organelle'. Recent structural analyses have begun to provide insights into how one of these microcompartments, the carboxysome, which houses ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase, is built. This Review describes the structure and function of bacterial microcompartments by focusing on carboxysomes.

Todd O. Yeates
Cheryl A. Kerfeld
Jessup M. Shively
Reviews04 Aug 2008
Nature Reviews Microbiology

Volume: 6, P: 681-691
Vertebrate Cryptochromes are Vestigial Flavoproteins

Roger J. Kutta
Nataliya Archipowa
Nigel S. Scrutton
ResearchOpen Access20 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
A KLK4 proteinase substrate capture approach to antagonize PAR1

Eitan Rabinovitch
Koishiro Mihara
Niv Papo
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-13
A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective

Larissa Vuitika
Nelson Côrtes
Gustavo Cabral-Miranda
ResearchOpen Access16 Oct 2024
Scientific Reports

Volume: 14, P: 1-17
Structure and antimicrobial activity of NCR169, a nodule-specific cysteine-rich peptide of Medicago truncatula

Noriyoshi Isozumi
Yuya Masubuchi
Shinya Ohki
ResearchOpen Access10 May 2021
Scientific Reports

Volume: 11, P: 1-12
Development of a cost-effective medium for Photorhabdus temperata bioinsecticide production from wastewater and exploration of performance kinetic

Sahar Keskes
Wafa Jallouli
Slim Tounsi
ResearchOpen Access12 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Ethnopharmacological study of native medicinal plants and the impact of pastoralism on their loss in arid to semiarid ecosystems of southeastern Iran

Mohsen Sharafatmandrad
Azam Khosravi Mashizi
ResearchOpen Access23 Sept 2020
Scientific Reports

Volume: 10, P: 1-18
Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells

Jing Jin
Richard D. Tarrant
Simon J. Draper
ResearchOpen Access17 Aug 2018
npj Vaccines

Volume: 3, P: 1-13
A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

Maria E. Lund
Judith Greer
Sheila Donnelly
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-11
Protective effects of seaweed supplemented diet on antioxidant and immune responses in European seabass (Dicentrarchus labrax) subjected to bacterial infection

Maria J. Peixoto
Renato Ferraz
Rodrigo O. A. Ozório
ResearchOpen Access06 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Unprecedented enhancement of recombinant protein production in sugarcane culms using a combinatorial promoter stacking system

Mona B. Damaj
John L. Jifon
Kranthi K. Mandadi
ResearchOpen Access13 Aug 2020
Scientific Reports

Volume: 10, P: 1-16
Production and Anticancer Activity of an L-Asparaginase from Bacillus licheniformis Isolated from the Red Sea, Saudi Arabia

S. A. Alrumman
Y. S. Mostafa
S. E. Elbehairi
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

O Susanto
S E Stewart
J A Trapani
Research07 Jun 2013
Cell Death & Differentiation

Volume: 20, P: 1183-1193
Caspase inhibitors

PG Ekert
J Silke
DL Vaux
Reviews24 Nov 1999
Cell Death & Differentiation

Volume: 6, P: 1081-1086

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