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Showing 1–15 of 15 results
Advanced filters: Author: O. H. Samuli Ollila Clear advanced filters

  • In this work, the authors report NMR lipids Databank to promote decentralised sharing of biomolecular molecular dynamics (MD) simulation data with an overlay design. Programmatic access enables analyses of rare phenomena and advances the training of machine learning models.

    • Anne M. Kiirikki
    • Hanne S. Antila
    • O. H. Samuli Ollila
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

    • Hanna M. Ollila
    • Eilon Sharon
    • Emmanuel J. Mignot
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Understanding the mechanisms underlying biological function in proteins relies on the ability to characterize their conformational structure, which remains challenging for multidomain proteins. Here, the authors introduce a protocol (QEBSS) that combines molecular dynamics simulations and nuclear magnetic resonance data to find experimentally validated conformational ensembles of flexible multidomain proteins, and demonstrate its advantages by applying it to study the dynamics of calmodulin, EN2, MANF, and CDNF.

    • Amanda E. Sandelin
    • Ricky Nencini
    • O. H. Samuli Ollila
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-13

  • Genome-wide association studies of individuals from an isolated population (data from the Finnish biobank study FinnGen) and consequent meta-analyses facilitate the identification of previously unknown coding variant associations for both rare and common diseases.

    • Mitja I. Kurki
    • Juha Karjalainen
    • Aarno Palotie
    ResearchOpen Access
    Nature
    Volume: 613, P: 508-518

  • To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism and cellular signaling.

    • Jonathan K. L. Mak
    • Chenxi Qin
    • Juulia Jylhävä
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 1589-1600

  • The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

    • Pradeep Natarajan
    • Akhil Pampana
    • Gina M. Peloso
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Identifying women at high risk of breast cancer has important implications for screening. Here, the authors demonstrate that polygenic risk scores improve breast cancer risk prediction in the population, in women with mutations in high-risk genes and in women with close relatives with the disease.

    • Nina Mars
    • Elisabeth Widén
    • Samuli Ripatti
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Peptides or proteins containing aggregates are pivotal for the integrity of structure and function, however, monitoring the dynamics of such systems remains challenging. Here, the authors investigate the dynamic landscape of peptide-SDS micelles through a synergistic combination of solution-state NMR experiments and molecular dynamics simulations.

    • Ricky Nencini
    • Morgan L. G. Regnier
    • O. H. Samuli Ollila
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-12

  • Cardiovascular diseases (CVD) are associated with plasma lipid levels. Here, Tabassum et al. perform genome-wide association studies for lipidomic profiles with 141 (non-standard) lipid species which highlights shared genetic loci with CVD and that traditional lipids have low genetic correlation with other lipids.

    • Rubina Tabassum
    • Joel T. Rämö
    • Samuli Ripatti
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

    • Erik L. Bao
    • Satish K. Nandakumar
    • Vijay G. Sankaran
    Research
    Nature
    Volume: 586, P: 769-775

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

  • Many genetic factors that contribute to uterine leiomyomata (UL) - the most common tumours of the female genital tract - remain to be discovered. Here, the authors conduct a UL meta-genome-wide association study, and find loci related to altered muscle tissue biology that are associated with UL.

    • Eeva Sliz
    • Jaakko S. Tyrmi
    • Johannes Kettunen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The largest meta-analysis of GWASs of hepcidin and sTfR identified 43 genomic loci, of which 15 new. Mendelian randomisation revealed associations of systemic iron status and iron-related loci with selected health outcomes across multiple domains.

    • Elias Allara
    • Steven Bell
    • Emanuele Di Angelantonio
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-17