Nature Search

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.

Siva Kumar Natarajan
Joanna Lum
Sriram Venneti
ResearchOpen Access04 Feb 2026
Nature

P: 1-12
Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy

An oral inulin allergen gel restores the microbiota of allergic mice and suppresses undesired immune responses to achieve allergen-specific oral tolerance, effectively overcoming food allergy.

Kai Han
Fang Xie
James J. Moon
Research08 Jul 2024
Nature Materials

Volume: 23, P: 1444-1455
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

An orally administered gel that is retained in the colon modulates the gut microbiome of mice with murine tumours, inducing systemic memory-T-cell responses and amplifying the antitumour activity of a checkpoint inhibitor.

Kai Han
Jutaek Nam
James J. Moon
Research24 Jun 2021
Nature Biomedical Engineering

Volume: 5, P: 1377-1388
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer

Achreja et al. develop a framework to identify collateral lethalities in cancer, uncovering MTHFD2 as a collateral lethal gene in UQCR11-deficient ovarian tumours.

Abhinav Achreja
Tao Yu
Deepak Nagrath
Research21 Sept 2022
Nature Metabolism

Volume: 4, P: 1119-1137
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours

Zhu et al. show how cancer-associated fibroblasts (CAFs) regulate metabolism of branched-chain amino acids in pancreatic ductal adenocarcinomas. CAFs secrete and deliver branched-chain ketoacids to cancer cells by degrading proteins in the extracellular matrix that are internalized from the tumour microenvironment.

Ziwen Zhu
Abhinav Achreja
Deepak Nagrath
Research06 Jul 2020
Nature Metabolism

Volume: 2, P: 775-792

Quick links

Search

Filter By:

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer

Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours

Search

Quick links