Search

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Charge quadrupole order was predicted in several 5d¹ and 5d² double perovskite systems, but experimental verification has been challenging. Here the authors provide experimental and theoretical evidence of simultaneous charge quadrupole order and local structural distortions in Ba₂MgReO₆.

An inverse design strategy is reported for the organization of nanoscale matter using DNA-programmable bonds and the fabrication of hierarchically ordered 3D assemblies.

Selective surface blocking allows for the regioselective DNA functionalization of nanoparticles and control over their self-assembly.

Phonon dynamics of self-assembled two-dimensional nanoparticle crystals is resolved by liquid-phase transmission electron microscopy.

DNA is a versatile molecular tool to program the assembly of organized three-dimensional nanostructures with precisely incorporated inorganic and biomolecular nanoscale components. This study reports an approach for growing 3D DNA-programmable frameworks on arbitrarily patterned silicon wafers and metal oxide surfaces.

A superlattice structure of gold tetrahedra formed via a surface-promoted pathway is reported. The octo-diamond crystal is achiral, but exhibits bilayers of left- and right-handed chiral motifs with chiroptical plasmonic responses.

As vesicles fuse to the plasma membrane, they form intermediate Ω-shaped structures followed by either closure of the pore or full merging with the plasma membrane. Here Wen et al. show that dynamic actin assembly provides membrane tension to promote Ω merging in neuroendocrine cells and synapses.

Organising proteins in 2D and 3D is needed to develop complex bimolecular materials for a range of applications. Here, the authors report the encapsulation of ferritin and apoferritin in DNA-based voxels with programmed assembly to generate both 2D and 3D protein lattices and demonstrate the retention of protein function.

Drug nanoaggregates could be used to improve drug pharmacokinetics when developed for drug delivery, however, the structural features of molecules that drive nanoaggregate formation remain elusive. Here, the authors investigate nanoaggregate self-assembly mechanisms using small molecule fragments to identify the critical molecular forces that contribute to self-assembly, namely aromatic groups and hydrogen bond acceptors/donors.

This paper demonstrates that the interactions between complementary DNA strands attached to nanoparticle surfaces can be tuned to drive the reversible formation of three-dimensional crystals with an open structure. The hope now is that the approach might be extended further, to provide easy access to new classes of ordered multicomponent materials with useful properties.

Solution-based syntheses of nanoscale clusters using biomolecules as links between nanoparticles are frequently inefficient and normally produce many different multimers or isomers of clusters. Dimer nanoclusters and Janus nanoclusters have now been designed and produced in high yields using nanoparticles grafted with single-stranded DNA.

Surface patterning of nanoparticles with polymer patches is achieved in a poor solvent for the polymer by controlling the ratio between the sizes of polymer molecules and nanoparticles.

Nanoparticles can be assembled into superlattices and dimer clusters using a reconfigurable DNA device that also allows interparticle distances to be modified, post-assembly, in response to molecular stimuli.

Two independent studies provide insight on the formation of nanocrystal superlattices and their atomic alignment using real-time in situ X-ray scattering techniques.

Colloidal particles interacting through DNA linkers can be designed to form solids that melt when either heated or cooled. This scenario widens the temperature window in which colloidal superlattices form by reducing kinetic bottlenecks.

Confinement-induced organization of nanoparticles is utilized to generate new structures with novel optical or magnetic properties. Here, Li et al.show that colloidal liquid crystals formed by rod-like nanoparticles self-assemble into various geometries depending on the degree of spherical confinement in droplets.

An operando mass spectrometry technique, along with molecular dynamics simulations, unveils the evolution of the solid–electrolyte interphase chemistry and structure in lithium-ion batteries during the first cycle.

Assembling nanoparticles into precise architectures by controlling their positions in three-dimensional space is a major challenge in nanoscience. Here, the authors construct complex, preprogrammed clusters of DNA-encoded nanoparticles by coordinating them onto a DNA mesh wireframe.

Fabrication of superconducting 3D nanoarchitectures, using standard nanofabrication methods, is challenging. Here, the authors demonstrate the fabrication of a nanostructured 3D superconducting array of Josephson junctions, exploiting self-assembled DNA origami lattices as a template.

Three-dimensional DNA frames can be created with controlled valence and coordination for the assembly of ordered arrays of biological and inorganic nanomaterials.

Nanoparticles with plasmonic, magnetic, catalytic and luminescent properties can be self-assembled into heterogeneous superlattices with the help of DNA.

Designed DNA-based polyhedral frames, whose vertices are connected to nanoparticles, facilitate their self-assembly into predetermined crystalline and open three-dimensional lattices.

A broadly applicable strategy that can control the self-assembly of nanoparticles into a predefined structure has been reported. Integrating nanoparticles with DNA constructs creates individual modules that can be assembled into complex planar architectures. The approach combines nanoparticles with the selectivity and directionality of bonds provided by DNA.

Octahedral DNA origami frames that have encoded vertices capable of attaching nanoparticles can be used to form precise three-dimensional nanoparticle clusters and one- and two-dimensional nanoparticle arrays.

Controlling self-assembly of nanoparticles into superlattices is an important approach to build functional materials. Here, Lu et al. use directional binding provided by DNA-encoded polyhedral blocks—cubes or octahedrons—to guide spherical nanoparticles into clusters and three-dimensional lattices.

The selective transformation of a DNA–nanoparticle superlattice into three-dimensional ‘daughter’ lattices is achieved by modifying interparticle interactions via reprogramming DNA strands.

This Perspective discusses how the Somatic Cell Genome Editing Consortium aims to accelerate the implementation of safe and effective genome-editing therapies in the clinic.