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Showing 1–2 of 2 results
Advanced filters: Author: Oleh Smutok Clear advanced filters

  • Protein-based nanobiosensors with two epistatically interacting synthetic allosteric regulatory systems result in YES gate protein switches with large dynamic ranges and fast response times. These biosensors enable construction of rapid diagnostic tests compatible with clinical chemistry analysers.

    • Zhong Guo
    • Oleh Smutok
    • Kirill Alexandrov
    Research
    Nature Nanotechnology
    Volume: 18, P: 1327-1334

  • Efforts to engineer artificial allosteric systems are ongoing. Here the authors analyse factors influencing development of artificial small molecule:protein complexes that act as chemically induced dimerization (CID) systems; they use one of the CIDs to construct an electrochemical biosensor of methotrexate.

    • Zhong Guo
    • Oleh Smutok
    • Kirill Alexandrov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13