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Showing 1–3 of 3 results
Advanced filters: Author: Olena Rudyk Clear advanced filters

  • Using mice with an amino substitution in the kinase PKG, a key regulator of blood vessel tone, Oleksandra Prysyazhna et al. provide evidence for the physiological importance of PKG oxidation and disulfide formation in maintaining normal blood pressure. These results clarify the nature of an enigmatic vasodilatory activity termed endothelium-derived hyperpolarizing factor and suggest that vascular oxidative stress can have blood pressure-lowering effects.

    • Oleksandra Prysyazhna
    • Olena Rudyk
    • Philip Eaton
    Research
    Nature Medicine
    Volume: 18, P: 286-290

  • The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphorylates phospholamban to enhance diastolic relaxation in mice.

    • Jenna Scotcher
    • Oleksandra Prysyazhna
    • Philip Eaton
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • The regulatory subunits (RI) of protein kinase A (PKA) form a disulfide bond in response to cellular hydrogen peroxide. Here the authors show that disulfide-activation of PKARIa regulates VEGF-induced angiogenesis in mice and may represent a new therapeutic target in diseases with abnormal angiogenesis.

    • Joseph R. Burgoyne
    • Olena Rudyk
    • Philip Eaton
    Research
    Nature Communications
    Volume: 6, P: 1-8