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Showing 1–4 of 4 results
Advanced filters: Author: Olena S. Tokareva Clear advanced filters

  • Identification of molecules that induce novel interactions between proteins has been limited by the complexity of rationally designing interactions. The authors report a method to discover molecular glue-like “trimerizers” based on α-helically constrained peptides that can co-opt the surfaces of E3 ubiquitin ligases to bind therapeutically important proteins.

    • Olena S. Tokareva
    • Kunhua Li
    • John H. McGee
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Reproducing many naturally occurring silk fibres—such as spider silk—remains a challenge. Here, the authors develop a predictive modelling approach to understand and design the artificial synthesis and fibre-spinning processes, which are tested in the laboratory to create de novobioinspired silk fibres.

    • Shangchao Lin
    • Seunghwa Ryu
    • Markus J. Buehler
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • Mirror-image phage display has the potential for high-throughput generation of biologically stable macrocyclic D-peptide binders but is hindered by the optimization required for D-protein chemical synthesis. Here, the authors report a general mirror-image phage display pipeline based on automated flow peptide synthesis and use it to prepare and characterize 12 L/D-protein pairs.

    • Alex J. Callahan
    • Satish Gandhesiri
    • Bradley L. Pentelute
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13