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Communications Biology (1)

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Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB

The study explores the activation mechanism of Staphylococcus aureus signal peptidase IB by the antibiotic PK150. We identified that PK150 shields the active site from excess water and stabilizes its catalytic geometry, thus enhancing catalysis.

Shu-Yu Chen
Michaela K. Fiedler
Martin Zacharias
ResearchOpen Access24 Jul 2024
Communications Biology

Volume: 7, P: 1-11

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Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB

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