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Serotonin 5-HT₄ receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin

Schill, Bijata, Kopach et al. show that 5-HT₄R activation leads to maturation of dendritic spines in hippocampal neurons via G13/RhoA signaling. The dendritic changes are complemented with corresponding changes in excitatory transmission, suggesting a role for 5-HT₄R in dendritic spine remodeling.

Yvonne Schill
Monika Bijata
Evgeni Ponimaskin
ResearchOpen Access14 Feb 2020
Communications Biology

Volume: 3, P: 1-16
Adenosine signalling to astrocytes coordinates brain metabolism and function

This study explores how adenosine A2B receptors can act as astrocytic sensors of brain metabolic activity and how cAMP signalling in astrocytes may support core brain functions such as sleep and memory.

Shefeeq M. Theparambil
Olga Kopach
Alexander V. Gourine
ResearchOpen Access03 Jul 2024
Nature

Volume: 632, P: 139-146
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Several mechanisms contribute to the maintenance of constant extracellular pH, essential for normal brain function. Here the authors show that astrocytes help to control local brain pH via a neuronal activity-dependent release of bicarbonate by the electrogenic sodium bicarbonate cotransporter 1.

Shefeeq M. Theparambil
Patrick S. Hosford
Alexander V. Gourine
ResearchOpen Access08 Oct 2020
Nature Communications

Volume: 11, P: 1-15
Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia

Olga Kopach
Noemí Esteras
Dmitri A. Rusakov
ResearchOpen Access17 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-12
Spinal PKCα inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons

Olga Kopach
Volodymyr Krotov
Nana Voitenko
ResearchOpen Access06 Jul 2018
Scientific Reports

Volume: 8, P: 1-14
Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI

Olga Kopach
Volodymyr Medvediev
Nana Voitenko
ResearchOpen Access19 Jul 2017
Scientific Reports

Volume: 7, P: 1-15
Multi-target action of β-alanine protects cerebellar tissue from ischemic damage

Olga Kopach
Dmitri A. Rusakov
Sergiy Sylantyev
ResearchOpen Access29 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-11
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

Gurvir S. Virdi
Minee L. Choi
Sonia Gandhi
ResearchOpen Access24 Nov 2022
npj Parkinson's Disease

Volume: 8, P: 1-22

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Serotonin 5-HT₄ receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin

Adenosine signalling to astrocytes coordinates brain metabolism and function

Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia

Spinal PKCα inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons

Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI

Multi-target action of β-alanine protects cerebellar tissue from ischemic damage

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

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