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Showing 1–5 of 5 results
Advanced filters: Author: Oliver C. Stringham Clear advanced filters

  • Mark McCarthy and colleagues identify twelve new risk loci for type 2 diabetes through a large-scale genome-wide association and replication study in individuals of European ancestry. The identified loci affect both beta-cell function and insulin action and are enriched for genes involved in cell cycle regulation.

    • Benjamin F Voight
    • Laura J Scott
    • Mark I McCarthy
    Research
    Nature Genetics
    Volume: 42, P: 579-589

  • This very large genome-wide association study identifies hundreds of new genetic variants influencing adult height in at least 180 loci enriched for genes involved in skeletal growth defects. The results show that the likely causal gene is often located near the most strongly associated variant, that many loci have multiple independently associated variants and that associated variants are enriched for likely functional effects on genes.

    • Hana Lango Allen
    • Karol Estrada
    • Joel N. Hirschhorn
    Research
    Nature
    Volume: 467, P: 832-838

  • The effect of sequence variants on phenotypes may depend on parental origin. Here, a method is developed that takes parental origin — the impact of which, to date, has largely been ignored — into account in genome-wide association studies. For 38,167 Icelanders genotyped, the parental origin of most alleles is determined; furthermore, a number of variants are found that show associations specific to parental origin, including three with type 2 diabetes.

    • Augustine Kong
    • Valgerdur Steinthorsdottir
    • Kari Stefansson
    Research
    Nature
    Volume: 462, P: 868-874

  • Despite reduced imports of amphibians targeted by a 2016 Lacey Act interim rule, an amphibian trade analysis suggests salamander populations in the US remain at risk from the fungal pathogen Batrachochytrium salamandrivorans due to sustained imports of other carrier taxa.

    • Patrick J. Connelly
    • Noam Ross
    • Evan A. Eskew
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 4, P: 1-10