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Showing 1–7 of 7 results
Advanced filters: Author: Oliver Kobler Clear advanced filters

  • Mutated tRNA synthetases can incorporate non-canonical amino acids into proteins. Erdmann et al. exploit this property to metabolically label newly synthesized proteins in selected cell types in Drosophila, and demonstrate their detection using proteomics (BONCAT) and fluorescence imaging (FUNCAT).

    • Ines Erdmann
    • Kathrin Marter
    • Daniela C. Dieterich
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Several K+ channels control neuronal excitability, but the function of KCNQ5 (Kv7.5), which displays wide expression in the brain, is not known. Here the authors show that KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition.

    • Pawel Fidzinski
    • Tatiana Korotkova
    • Thomas J. Jentsch
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • The mushroom body of Drosophila integrates sensory information with past experience to guide behaviour. Here, the authors provide an atlas of the input and output neurons of the stage 3 larval mushroom body at the single-cell level, and analyse their function in learned and innate behaviours.

    • Timo Saumweber
    • Astrid Rohwedder
    • Bertram Gerber
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-19

  • There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminals

    • Maria Andres-Alonso
    • Mohamed Raafet Ammar
    • Michael R. Kreutz
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17