Nature Search

Salient and contested scientific evidence in debates over sustainable transformation: pesticide policymaking in Switzerland

Oliver Truffer
Benjamin Hofmann
Eva Lieberherr
ResearchOpen Access05 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-16
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics and enhance central nervous system tumor subtype classification.

Michael Ritter
Christina Blume
Felix Sahm
ResearchOpen Access29 Jan 2025
Nature Cancer

Volume: 6, P: 292-306
Search strategies the answer

Oliver Dearlove
Correspondence03 Oct 1996
Nature

Volume: 383, P: 384
Light storage in light cages: a scalable platform for multiplexed quantum memories

We implement 3D-nanoprinted hollow-core waveguides—so-called light cages—as atomic vapor-based quantum memories. These structures significantly enhance light–matter interactions within a compact, chip-integrated platform, marking a step forward in scalable and versatile photonic quantum technologies.

Esteban Gómez-López
Dominik Ritter
Oliver Benson
ResearchOpen Access01 Jan 2026
Light: Science & Applications

Volume: 15, P: 1-10
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.

Alex H. Wagner
Siddhartha Devarakonda
Ramaswamy Govindan
ResearchOpen Access17 Sept 2018
Nature Communications

Volume: 9, P: 1-11
Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships

A method integrates perturbation mapping with 10X Visium spatial transcriptomics to map tumour genetic complexity and heterogeneity.

Marco Breinig
Artem Lomakin
Darjus F. Tschaharganeh
ResearchOpen Access28 Jul 2025
Nature Biomedical Engineering

Volume: 10, P: 125-143
Defining consciousness

Oliver Sacks
Correspondence20 Aug 1992
Nature

Volume: 358, P: 618
Sandoz-funded research from Rhine spill suggests blockages are worse than toxins

Oliver Klaffke
Alison Abbot
News15 Oct 1992
Nature

Volume: 359, P: 568
Oxidising agents in sub-arc mantle melts link slab devolatilisation and arc magmas

The oxidised nature of arc magmas is either attributed to recycling from the slab or magma differentiation. Here, the authors show that oxidised iron and sulfur, respectively in sub-arc mantle spinel and glass inclusions with elevated U/Th, Pb/Ce, Sr/Nd and δ³⁴S, trace dehydration products of slab serpentinites.

Antoine Bénard
Kevin Klimm
Dmitri A. Ionov
ResearchOpen Access29 Aug 2018
Nature Communications

Volume: 9, P: 1-10
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

Rebekka Wegmann
Ximena Bonilla
Alexandre P. A. Theocharides
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4⁺ T cells and collagen, and how different collagen matrices restrict infection by cell-free virions.

Andrea Imle
Peter Kumberger
Oliver T. Fackler
ResearchOpen Access13 May 2019
Nature Communications

Volume: 10, P: 1-18
Retinoblastoma outcomes in Europe: a prospective analysis of 483 patients from 40 countries

Richard Bowman
Mattan Arazi
Richard Bowman
Research17 Dec 2025
Eye

P: 1-9
Ectopic callose deposition into woody biomass modulates the nano-architecture of macrofibrils

Bourdon et al. demonstrate the possibility to ectopically synthesize callose, a polymer restricted to primary cell walls, into Arabidopsis and aspen secondary cell walls to manipulate their ultrastructure and ultimately reduce their recalcitrance.

Matthieu Bourdon
Jan J. Lyczakowski
Ykä Helariutta
ResearchOpen Access04 Sept 2023
Nature Plants

Volume: 9, P: 1530-1546
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

Understanding the immune response to SARS-CoV-2 is dependent on being able to distinguish COVID-19 immune responses from cross-reactive immune responses to other coronaviruses. Here the authors show that choice of antigens and whether an ICS, ELISPOT or T cell proliferation assay is used has a major effect on this discriminatory ability.

Ane Ogbe
Barbara Kronsteiner
Susanna Dunachie
ResearchOpen Access06 Apr 2021
Nature Communications

Volume: 12, P: 1-14
A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei

Sleeping sickness is caused by the parasite Trypanosoma brucei. This parasite outwits the human immune system by periodically changing its coat protein in a process known as VSG switching. Here, the first in vitro system that recapitulates VSG switching is established, indicating that a spontaneous double-stranded DNA break upstream of the gene encoding the code protein initiates the process.

Catharine E. Boothroyd
Oliver Dreesen
F. Nina Papavasiliou
Research15 Apr 2009
Nature

Volume: 459, P: 278-281
Phosphorylation in liquid sulfur dioxide under prebiotically plausible conditions

Organophosphates are essential to facilitate information storage and energy transfer in living organisms, but their prebiotic origins remain unknown. Here, the authors report a liquid sulfur dioxide-mediated phosphorylation of nucleosides from phosphorous acid in a single reaction step at room temperature.

Constanze Sydow
Christiane Seiband
Oliver Trapp
ResearchOpen Access03 Nov 2022
Communications Chemistry

Volume: 5, P: 1-10
Correlation between deep fluids, tremor and creep along the central San Andreas fault

Michael Becken
Oliver Ritter
Ute Weckmann
Research30 Nov 2011
Nature

Volume: 480, P: 87-90
Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers

Mengjun Dai
Kangbo Li
Philipp Hillmeister
ResearchOpen Access05 Dec 2024
Scientific Reports

Volume: 14, P: 1-11
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Azmeraw T. Amare
Anbupalam Thalamuthu
Bernhard T. Baune
ResearchOpen Access11 Jul 2023
Molecular Psychiatry

Volume: 28, P: 5251-5261
Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Liang-Yu Huang
Chen-Chen Tan
Dariella Fernandez
ResearchOpen Access08 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-11
Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy

Alexander Bernt
Ashraf Y. Rangrez
Norbert Frey
ResearchOpen Access21 Oct 2016
Scientific Reports

Volume: 6, P: 1-15
Limitations in next-generation sequencing-based genotyping of breast cancer polygenic risk score loci

Alexandra Baumann
Christian Ruckert
Corinna Ernst
ResearchOpen Access21 Jun 2024
European Journal of Human Genetics

Volume: 32, P: 987-997
CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

Recent studies have shown that neutrophil extracellular traps (NETs) can capture and kill bacteria but may also contribute to chronic inflammation. The mechanisms that trigger NET formation are not yet fully elucidated. Marcos et al. now report that stimulation of the chemokine receptor CXCR, induces NET formation and that NETs are present in airway fluids of individuals with cystic fibrosis. Blocking CXCR2 activation in the lung reduced NET formation and improved lung function in a mouse model of cystic fibrosis.

Veronica Marcos
Zhe Zhou
Dominik Hartl
Research05 Sept 2010
Nature Medicine

Volume: 16, P: 1018-1023
Adverse socioeconomic factors are associated with a widening gap in one-year health-related quality of life after acute myocardial infarction

David Füller
Henrike Andresen-Bundus
Benjamin Sasko
ResearchOpen Access05 Jun 2025
Scientific Reports

Volume: 15, P: 1-10
CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression

Miriam Saponaro
Sina Flottmann
Abdullah Alajati
ResearchOpen Access02 Jan 2023
Scientific Reports

Volume: 13, P: 1-19
Author Correction: CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression

Miriam Saponaro
Sina Flottmann
Abdullah Alajati
Amendments and CorrectionsOpen Access17 Feb 2023
Scientific Reports

Volume: 13, P: 1
Synchronous vegetation response to the last glacial-interglacial transition in northwest Europe

Vegetation across northwest Europe responded instantly and synchronously to abrupt cooling during the last deglaciation, according to a compilation of precisely dated terrestrial records.

Stefan Engels
Christine S. Lane
Frederike Wagner-Cremer
ResearchOpen Access09 Jun 2022
Communications Earth & Environment

Volume: 3, P: 1-10
Repeat bleaching of a central Pacific coral reef over the past six decades (1960–2016)

Hannah Barkley and Anne Cohen and colleagues used bleaching signatures in coral skeletons to examine the Jarvis Island coral community response to multiple El Niño heatwaves. They find the historically productive ecosystem experienced 10 bleaching events in the past 60 years and its recovery provides insights into coral reef resilience under ocean warming.

Hannah C. Barkley
Anne L. Cohen
Victoria H. Luu
ResearchOpen Access08 Nov 2018
Communications Biology

Volume: 1, P: 1-10
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores

The Polygenic Risk Score Knowledge Base (PRSKB) is a web-based interface that stores data from >2,300 distinct genome-wide association studies, and can estimate polygenic risk scores for general use.

Madeline L. Page
Elizabeth L. Vance
John S. K. Kauwe
ResearchOpen Access02 Sept 2022
Communications Biology

Volume: 5, P: 1-15
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Digital implant planning and guided implant surgery – workflow and reliability

O. Schubert
J. Schweiger
J.-F. Güth
Research25 Jan 2019
British Dental Journal

Volume: 226, P: 101-108
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10

Search

Salient and contested scientific evidence in debates over sustainable transformation: pesticide policymaking in Switzerland

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics

Search strategies the answer

Light storage in light cages: a scalable platform for multiplexed quantum memories

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships

Defining consciousness

Sandoz-funded research from Rhine spill suggests blockages are worse than toxins

Oxidising agents in sub-arc mantle melts link slab devolatilisation and arc magmas

Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

Retinoblastoma outcomes in Europe: a prospective analysis of 483 patients from 40 countries

Ectopic callose deposition into woody biomass modulates the nano-architecture of macrofibrils

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei

Phosphorylation in liquid sulfur dioxide under prebiotically plausible conditions

Correlation between deep fluids, tremor and creep along the central San Andreas fault

Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers

Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy

Limitations in next-generation sequencing-based genotyping of breast cancer polygenic risk score loci

CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

Adverse socioeconomic factors are associated with a widening gap in one-year health-related quality of life after acute myocardial infarction

CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression

Author Correction: CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression

Synchronous vegetation response to the last glacial-interglacial transition in northwest Europe

Repeat bleaching of a central Pacific coral reef over the past six decades (1960–2016)

Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores

A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Digital implant planning and guided implant surgery – workflow and reliability

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

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