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Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo

The selective autophagy receptor p62/SQSTM1 is organized in a structured double helical filament in vitro, the cryo-electron tomographic images in ATG5 knockdown conditions reveal Ca-rich layers of p62 oligomers enwrapping lipid droplets in situ.

Sabrina Berkamp
Lisa Jungbluth
Carsten Sachse
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-21

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Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo

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