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Showing 1–2 of 2 results
Advanced filters: Author: Olivia N. Attrebi Clear advanced filters

  • C9orf72 ALS/FTD polyGR and polyPR knock-in mice show cortical hyperexcitability and motor neuron loss accompanied by an increase in extracellular matrix proteins in the spinal cord that is conserved in patient iPS cell-derived neurons and is neuroprotective.

    • Carmelo Milioto
    • Mireia Carcolé
    • Adrian M. Isaacs
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 643-655

  • The APOE ε4 allele is a strong genetic risk factor for Alzheimer’s disease, whereas the APOE ε2 allele is protective. Here the authors show that mice expressing the human APOE ε2/ε2 genotype have increased tau pathology and related behavioral deficits; they also find that the APOE ε2 allele is associated with an increased burden of tau pathology in postmortem human brains with progressive supranuclear palsy.

    • Na Zhao
    • Chia-Chen Liu
    • Guojun Bu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11