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Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations

Here, as part of the Sherlock-Lung study, the authors profile the microbiomes of 940 lung cancers in never smokers finding no significant associations with demographic and clinical features, suggesting lung bacteria are unlikely to have a sizable role in lung cancer.

John P. McElderry
Tongwu Zhang
Maria Teresa Landi
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Epoxy-oxylipins direct monocyte fate in inflammatory resolution in humans

Here they demonstrate a therapeutic intervention elevating levels of CYP450-derived lipids to control the expansion of intermediate monocytes in tissue and peripheral blood, presenting a first in class therapeutic approach for treating chronic inflammatory disease.

Olivia V. Bracken
Parinaaz Jalali
Derek W. Gilroy
ResearchOpen Access16 Jan 2026
Nature Communications

Volume: 17, P: 1-17
Gut bacterial dysbiosis in pediatric severe malaria associates with post-discharge mortality

In this study, the authors show that gut dysbiosis in African children with severe malaria may contribute to the pathogenesis of malaria, including an increased risk of post-discharge mortality.

Olivia J. Bednarski
Sawyer B. Lehman
Nathan W. Schmidt
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-18
Publisher Correction: Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

Roel P. H. De Maeyer
Rachel C. van de Merwe
Derek W. Gilroy
Amendments and Corrections17 Apr 2020
Nature Immunology

Volume: 21, P: 696
Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia

The post-resolution phase of inflammation is not simply a linear path towards cessation of immune response but rather a regulated process involving fluctuating immune activity. Here authors show a pivotal role for post-resolution macrophages in driving a wave of T cell recruitment and activation via prostaglandin E2 and α-integrin signalling during the resolution phase of murine pneumococcal pneumonia.

Karen T. Feehan
Hannah E. Bridgewater
Derek W. Gilroy
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-17
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

Human aging is characterized by an elevated basal inflammatory state. Gilroy and colleagues use a tractable in vivo human inflammation model to demonstrate a mechanism whereby efferocytosis is impaired in the elderly but is reversible by p38 inhibition.

Roel P. H. De Maeyer
Rachel C. van de Merwe
Derek W. Gilroy
Research06 Apr 2020
Nature Immunology

Volume: 21, P: 615-625
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Seronegative healthcare workers with an innate signature of infection preferentially expand pre-existing T cells targeting the conserved replication transcription complex of SARS-CoV-2 in abortive infection.

Leo Swadling
Mariana O. Diniz
Mala K. Maini
ResearchOpen Access10 Nov 2021
Nature

Volume: 601, P: 110-117
Enhancing immunity during ageing by targeting interactions within the tissue environment

Immune dysfunction increases with age owing to cellular senescence and low-grade inflammation, processes that drive each other during ageing. This Review discusses the potential of therapeutic approaches that target interactions between the tissue environment and the immune system by eliminating senescent cells, inhibiting inflammation and boosting immune function.

Olivia V. Bracken
Roel P. H. De Maeyer
Arne N. Akbar
Reviews28 Jan 2025
Nature Reviews Drug Discovery

Volume: 24, P: 300-315

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