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Showing 1–5 of 5 results
Advanced filters: Author: Olivier Arnaiz Clear advanced filters

  • A study of the duplicated genes in Paramecium tetraurelia suggests that after whole-genome duplication events, many duplicated genes are not able to immediately functionally diverge, because dosage constraints act on them. These dosage constraints also prevent loss of many duplicated genes after whole genome duplications.

    • Jean-Marc Aury
    • Olivier Jaillon
    • Patrick Wincker
    ResearchOpen Access
    Nature
    Volume: 444, P: 171-178

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • H3K9me3 and H3K27me3 chromatin silencing marks are usually deposited by different SET-domain proteins. Here the authors show that the Enhancer-of-zeste-like protein Ezl1, from the unicellular eukaryote Paramecium tetraurelia, catalyzes methylation of histone H3 in vitro and in vivo with an apparent specificity toward K9 and K27, and controls the repression of transposable elements.

    • Andrea Frapporti
    • Caridad Miró Pina
    • Sandra Duharcourt
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The molecular basis for mating-type determination in the ciliate Paramecium has been elucidated, revealing a novel function for a class of small RNAs — these scnRNAs are typically involved in reprogramming the Paramecium genome during sexual reproduction by recognizing and excising transposable elements, but they are now found to be co-opted to switch off expression of the newly identified mating-type gene mtA by excising its promoter, and to mediate epigenetic inheritance of mating types across sexual generations.

    • Deepankar Pratap Singh
    • Baptiste Saudemont
    • Eric Meyer
    Research
    Nature
    Volume: 509, P: 447-452