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Showing 1–9 of 9 results
Advanced filters: Author: Omer Revah Clear advanced filters

  • The transplantation of human cortical organoids in rats enables maturation and integration of human neural cells that can engage with the host circuitry, providing a framework to study alterations in morphology and physiology of patient-derived tissue.

    • Kevin W. Kelley
    • Omer Revah
    • Sergiu P. Pașca
    Protocols
    Nature Protocols
    Volume: 19, P: 3542-3567

  • Antisense oligonucleotides effectively decrease the inclusion of exon  8A of CACNA1C in human cells both in vitro and in rodents transplanted with human brain organoids, and a single intrathecal administration rescued both calcium changes and in vivo dendrite morphology of patient neurons.

    • Xiaoyu Chen
    • Fikri Birey
    • Sergiu P. Pașca
    ResearchOpen Access
    Nature
    Volume: 628, P: 818-825

  • A protocol adapted to xeno- and feeder-free conditions is shown to generate reliable and consistent cortical brain organoids across differentiations and source stem cell lines, making it suitable for disease modeling and other applications.

    • Se-Jin Yoon
    • Lubayna S. Elahi
    • Sergiu P. Pașca
    Research
    Nature Methods
    Volume: 16, P: 75-78

  • Brain organoids derived from human iPSCs are used to study the effects of hypoxia on early cortical neurodevelopment and identify defects in specific human progenitor populations that likely contribute to encephalopathy of prematurity.

    • Anca M. Pașca
    • Jin-Young Park
    • Sergiu P. Pașca
    Research
    Nature Medicine
    Volume: 25, P: 784-791

  • A protocol is described for generating human brain assembloids and performing viral labeling and retrograde tracing, 3D live imaging of axon projection and optogenetics with calcium imaging and electrophysiological recordings to model neural circuits.

    • Yuki Miura
    • Min-Yin Li
    • Sergiu P. Pașca
    Protocols
    Nature Protocols
    Volume: 17, P: 15-35