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Showing 1–3 of 3 results
Advanced filters: Author: Omkar Zilka Clear advanced filters

  • Genetic screens reveal a compendium of metabolic modifiers of lipid peroxidation. Tetrahydrobiopterin is essential under GPX4 inhibition, acting as a radical-trapping antioxidant that inhibits lipid peroxidation and is regenerated by DHFR.

    • Mariluz Soula
    • Ross A. Weber
    • Kıvanç Birsoy
    Research
    Nature Chemical Biology
    Volume: 16, P: 1351-1360

  • Proferroptotic activity of 7-dehydrocholesterol reductase is shown along with an unexpected prosurvival function of its substrate, 7-dehydrocholesterol, indicating a cell-intrinsic mechanism that could be used by cancer cells to protect phospholipids from oxidative damage and escape ferroptosis.

    • Florencio Porto Freitas
    • Hamed Alborzinia
    • José Pedro Friedmann Angeli
    Research
    Nature
    Volume: 626, P: 401-410

  • Biochemical and lipidomic analyses identify an anti-ferroptotic function of vitamin K and reveal ferroptosis suppressor protein 1 (FSP1) as the enzyme mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle.

    • Eikan Mishima
    • Junya Ito
    • Marcus Conrad
    ResearchOpen Access
    Nature
    Volume: 608, P: 778-783