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Showing 1–9 of 9 results
Advanced filters: Author: Ori D. Fox Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • The authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease.

    • Femke M. Feringa
    • Sascha J. Koppes-den Hertog
    • Rik van der Kant
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 2142-2164

  • We describe a human DNA methylome atlas based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis of cell-type-specific markers and providing an essential resource for studies of gene regulation and for deconvolution of cell mixtures and liquid biopsies.

    • Netanel Loyfer
    • Judith Magenheim
    • Tommy Kaplan
    ResearchOpen Access
    Nature
    Volume: 613, P: 355-364

  • Silk fibers’ unique properties make them desirable for various applications. However, no synthetic method has reproduced this tough biomaterial due to poor understanding of their complex formation mechanism. Here, the authors map the natural composition of metal ions that guide the protein structural transformations during the fiber’s spinning process.

    • Ori Brookstein
    • Eyal Shimoni
    • Ulyana Shimanovich
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • JWST observations reveal more than 17 nested dust shells that formed in the colliding winds of the massive binary WR 140 that enrich the surrounding interstellar medium with organic compounds and carbon-rich dust.

    • Ryan M. Lau
    • Matthew J. Hankins
    • Ryodai Yamaguchi
    Research
    Nature Astronomy
    Volume: 6, P: 1308-1316

  • For many neurodevelopmental disorder (NDD) risk genes, the significance for mutational burden is unestablished. Here, the authors sequence 125 candidate NDD genes in over 16,000 NDD cases; case-control mutational burden analysis identifies 48 genes with a significant burden of severe ultra-rare mutations.

    • Tianyun Wang
    • Kendra Hoekzema
    • Evan E. Eichler
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The formation of dust in the dense circumstellar medium of the bright supernova 2010jl is at first rapid and produces very large grains, which resist destruction, whereas later the dust production rate increases, meaning its source is ejecta; this links early and late dust mass evolution in supernovae with dense circumstellar media.

    • Christa Gall
    • Jens Hjorth
    • Avril C. Day-Jones
    Research
    Nature
    Volume: 511, P: 326-329