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Showing 1–4 of 4 results
Advanced filters: Author: Ori Pearl Clear advanced filters

  • Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.

    • Christian Koelsche
    • Daniel Schrimpf
    • Andreas von Deimling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • The differential effects of TP53 missense mutations in colorectal cancer (CRC) remain to be explored. Here the authors compare the gain of function impact of two frequent TP53 mutations in CRC and show that p53R273 mutants control a transcriptional program, which drives oncogenic signaling pathways, leading to a more aggressive phenotype and worse patient outcome.

    • Ori Hassin
    • Nishanth Belugali Nataraj
    • Moshe Oren
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

    • David Capper
    • David T. W. Jones
    • Stefan M. Pfister
    Research
    Nature
    Volume: 555, P: 469-474