Nature Search

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Pulmonary hypertension due to left heart disease is characterized by pulmonary arterial stiffening that results from extracellular matrix remodeling. Here, the authors show that elastin stabilization improves arterial biomechanics and attenuates pulmonary hypertension.

Mariya M. Kucherenko
Pengchao Sang
Christoph Knosalla
ResearchOpen Access21 Jul 2023
Nature Communications

Volume: 14, P: 1-23
dsRNA formation leads to preferential nuclear export and gene expression

Antisense RNAs boost gene expression by accelerating the export of mRNA from the nucleus to the cytoplasm through the Dbp2-mediated formation of double-stranded RNAs, which might explain the prevalence of antisense RNAs.

Ivo Coban
Jan-Philipp Lamping
Heike Krebber
ResearchOpen Access19 Jun 2024
Nature

Volume: 631, P: 432-438
DNA methylation changes in plasticity genes accompany the formation and maintenance of memory

Learning and memory processes require experience-dependent changes in chromatin modifications. Here the authors provide a detailed view of the gene regulatory roles of DNA methylation and histone modifications during the acquisition and maintenance of memory across different cell types and brain regions.

Rashi Halder
Magali Hennion
Stefan Bonn
Research14 Dec 2015
Nature Neuroscience

Volume: 19, P: 102-110
A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease

Orr Shomroni
Maren Sitte
Gabriela Salinas
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-14
Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies

Dordevic, Dierks et al. investigate factors influencing the circulating proteome in multi-country population cohorts. Many demographic covariates and common medications affect concentrations of highly abundant plasma proteins, but the most significant changes were linked to the use of hormonal contraceptives.

Nikola Dordevic
Clemens Dierks
Markus Ralser
ResearchOpen Access22 Apr 2025
Communications Medicine

Volume: 5, P: 1-12
Genome-wide chromatin and gene expression profiling during memory formation and maintenance in adult mice

Tonatiuh Pena Centeno
Orr Shomroni
Stefan Bonn
ResearchOpen Access11 Oct 2016
Scientific Data

Volume: 3, P: 1-21
Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons

Sinem M. Sertel
Wiebke Blumenstein
Silvio O. Rizzoli
ResearchOpen Access30 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing

Björn Friedhelm Vahsen
Vinicius Toledo Ribas
Paul Lingor
ResearchOpen Access27 Apr 2020
Cell Death & Differentiation

Volume: 27, P: 2810-2827
Screening for potential targets to reduce stenosis in bioprosthetic heart valves

Rudi Foth
Orr Shomroni
Katja Eildermann
ResearchOpen Access28 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis

Merit Wildung
Tilman Uli Esser
Muriel Lizé
Research08 May 2019
Cell Death & Differentiation

Volume: 26, P: 2740-2757

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