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Showing 1–3 of 3 results
Advanced filters: Author: Osama F. Harraz Clear advanced filters

  • On-demand blood flow increases are essential for brain health, but how flow recovers is unclear. Here, the authors show that brain perfusion triggers vascular Piezo1-mediated mechano-feedback that promotes blood flow recovery to baseline levels.

    • Xin Rui Lim
    • Mohammad M. Abd-Alhaseeb
    • Osama F. Harraz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Metals such as calcium and potassium have long been known to regulate the diameter of arteries that control blood flow. Here, we report that zinc causes relaxation of blood vessels and reduces blood pressure by its coordinated action in sensory nerves, endothelium and smooth muscle cells.

    • Ashenafi H. Betrie
    • James A. Brock
    • Scott Ayton
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Giant cell lesions of the jaw (GCLJ) are debilitating benign tumors of unclear origin. The authors identify driver recurrent somatic mutations in TRPV4, KRAS and FGFR1 and show they converge on aberrant activation of the MAPK pathway. Their findings extend the spectrum of TRPV4 channelopathies and provide rationale for targeted therapies at the bedside in GCLJ.

    • Carolina Cavalieri Gomes
    • Tenzin Gayden
    • Nada Jabado
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8