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Showing 1–3 of 3 results
Advanced filters: Author: Osami Shoji Clear advanced filters

  • Nuclear import receptors (NIRs) regulate self-association of RNA-binding proteins as phase modifiers, while C9orf72-derived arginine-rich polydipeptides lead to aberrant phase transitions. Here the authors show in molecular basis how arginine-rich poly-dipeptides impede the ability of NIRs, particularly Kapβ2.

    • Hitoki Nanaura
    • Honoka Kawamukai
    • Eiichiro Mori
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Using photosensitive caged-compound for femtosecond crystallography at X-ray free electron lasers would allow the structure determination of reaction intermediates. Here the authors demonstrate the feasibility of this approach with a caged NO-compound and present the initial NO-bound intermediate structure of cytochrome P450 nitric oxide reductase.

    • Takehiko Tosha
    • Takashi Nomura
    • Minoru Kubo
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Understanding the structural dynamics and protein-substrate interactions for the bacterial cytochrome P450BM3, a haem-containing enzyme, is a prerequisite for its application as a biocatalyst. Here, the authors use X-ray free electron laser crystallography to determine the intermediate structures of engineered P450BM3 during styrene epoxidation, probing the dynamic control of styrene orientation for the enantioselectivity of the reaction.

    • Satoshi Nagao
    • Wako Kuwano
    • Minoru Kubo
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-11