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Showing 1–10 of 10 results
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  • Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) is important for invasion of reticulocytes and PvRBP2b antibodies correlate with protection. Here, Chan et al. isolate and characterize anti-PvRBP2b human monoclonal antibodies and describe mechanisms by which these antibodies inhibit invasion.

    • Li-Jin Chan
    • Anugraha Gandhirajan
    • Wai-Hong Tham
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • In apicomplexan parasites, the conoid is a dynamic organelle of enigmatic function. This study establishes that the conoid movement is essential to control the flux of F-actin needed for myosin-dependent motility that powers invasion and egress.

    • Nicolas Dos Santos Pacheco
    • Lorenzo Brusini
    • Dominique Soldati-Favre
    Research
    Nature Microbiology
    Volume: 7, P: 1777-1790

  • High-resolution structures of phosphatidylinositol 3-kinase (PI3K) type IIa unravel a coincident mechanism of lipid-induced enzyme activation and enable the development of inhibitors of class II PI3K function with applications in biomedicine.

    • Wen-Ting Lo
    • Yingyi Zhang
    • Volker Haucke
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 218-228

  • Host cell invasion by Toxoplasma gondii depends on the heavily phosphorylated RON complex, but the relevance and regulation of these modifications are not understood. Here, the authors identify the kinase RON13 as a key virulence factor, determine its structure and show that it phosphorylates the RON complex.

    • Gaëlle Lentini
    • Rouaa Ben Chaabene
    • Dominique Soldati-Favre
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • When tubulin proteins are present in excess, their encoding mRNAs are selectively degraded in a process initiated by the protein TTC5. Here, the authors show that tubulins themselves reversibly sequester TTC5 to regulate its activity.

    • Alina Batiuk
    • Markus Höpfler
    • Ivana Gasic
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The authors uncover one of the largest mitoribosomes, dedicated to translating only three proteins in lethal human eukaryotic pathogens of the Apicomplexa phylum. All members of mitochondrial DNA-containing Myzozoa, including Toxoplasma gondii, have commandeered three lineage-specific families of RNA-binding proteins to meticulously piece together over 40 mitochondrial rRNA fragments to build an operational mitoribosome.

    • Chaoyue Wang
    • Sari Kassem
    • Yonggen Jia
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Inositol pyrophosphates are key nutrient messengers in fungi, plants and animals. This study uncovers the structure and function of a critical enzyme involved in their production and breakdown, revealing how cells control inositol pyrophosphate levels to regulate nutrient signaling.

    • Pierre Raia
    • Kitaik Lee
    • Michael Hothorn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Coenzyme A (CoA) is an essential metabolite found in all organisms and its synthesis involves five conserved enzymatic steps and uses pantothenate (Pan) as a precursor. Here, Lunghi et al. examine the Pan synthesis pathway in Toxoplasma gondii and find that Pan is crucial for the establishment of chronic but not acute infection.

    • Matteo Lunghi
    • Joachim Kloehn
    • Dominique Soldati-Favre
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18