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Showing 1–12 of 12 results
Advanced filters: Author: Oskar Maier Clear advanced filters

  • Biomedical image analysis challenges have increased in the last ten years, but common practices have not been established yet. Here the authors analyze 150 recent challenges and demonstrate that outcome varies based on the metrics used and that limited information reporting hampers reproducibility.

    • Lena Maier-Hein
    • Matthias Eisenmann
    • Annette Kopp-Schneider
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • The PSA (KLK3) genetic variant rs17632542 is associated with reduced prostate cancer risk and lower serum PSA levels, although the underlying reasons are unclear. Here, the authors show that this PSA variant reduced proteolytic activity and leads to smaller tumours, but also increases invasion and bone metastasis, indicating its dual risk association depending on tumour context; the variant is associated with both lower risk and poor clinical outcomes.

    • Srilakshmi Srinivasan
    • Thomas Kryza
    • Jyotsna Batra
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature Physics
    Volume: 19, P: 237-253

  • The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

    • Jan Rozman
    • Birgit Rathkolb
    • Martin Hrabe de Angelis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

    • Michael R. Bowl
    • Michelle M. Simon
    • Steve D. M. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Discovery of causal variants for monogenic disorders has been facilitated by whole exome and genome sequencing, but does not provide a diagnosis for all patients. Here, the authors propose a Full Spectrum of Intolerance to Loss-of-Function (FUSIL) categorization that integrates gene essentiality information to aid disease gene discovery.

    • Pilar Cacheiro
    • Violeta Muñoz-Fuentes
    • Coleen Kane
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Despite comprising only about 15% of the known molecular inventory of the interstellar medium, molecular ions have an outsized role in driving chemical evolution. This Review examines the advances — and challenges — in laboratory spectroscopy that have enabled the study of ions in space.

    • Brett A. McGuire
    • Oskar Asvany
    • Stephan Schlemmer
    Reviews
    Nature Reviews Physics
    Volume: 2, P: 402-410

  • High-resolution X-ray spectra show near-solar abundances of chromium, manganese and nickel with respect to iron in the Perseus cluster, suggesting that the progenitors of type Ia supernovae could be near- and sub-Chandrasekhar-mass white dwarfs.

    • Felix Aharonian
    • Hiroki Akamatsu
    • Abderahmen Zoghbi
    Research
    Nature
    Volume: 551, P: 478-480