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Showing 1–7 of 7 results
Advanced filters: Author: Oskar Staufer Clear advanced filters

  • Synthetic cells have huge potential in model systems. Here, the authors engineer synthetic–living hybrid tumoroids that replicate tumour-immune interactions in 3D, study synthetic cells integration, and demonstrate systematic studies of immune evasion and T cell engager therapies.

    • Nils Piernitzki
    • Ning Gao
    • Oskar Staufer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Staufer et al. provide a protocol for preparation of synthetic minimal virions (MiniV) of SARS-CoV-2, mimicking viral structure and allowing for precise investigation of receptor binding mechanism. They find that the highly conserved free fatty acid binding pocket (FABP) can function as an allosteric regulator, enabling adaptation of immunogenicity via binding of proinflammatory free fatty acids and mediating the spike open to-closed equilibrium.

    • Oskar Staufer
    • Kapil Gupta
    • Joachim P. Spatz
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • In a major advancement for synthetic biology, dynamin A has been identified as a minimal component enabling cell division in synthetic cells, moving us one step nearer to realizing the ambition of creating synthetic life forms.

    • Oskar Staufer
    News & Views
    Nature Nanotechnology
    Volume: 19, P: 3-4

  • Deep learning frameworks require large human-annotated datasets for training and the resulting ‘black box’ models are difficult to interpret. Here, the authors present Kartezio; a modular Cartesian Genetic Programming-based computational strategy that generates fully transparent and easily interpretable image processing pipelines.

    • Kévin Cortacero
    • Brienne McKenzie
    • Sylvain Cussat-Blanc
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • BriSΔ, a SARS-CoV-2 variant from clinical isolate hCoV/England/02/2020, comprises a deletion in a spike cleavage site. The structure and molecular dynamics of this spike provides mechanistic insights into how the deletion modulates virus infectivity.

    • Kapil Gupta
    • Christine Toelzer
    • Imre Berger
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.

    • Omer Adir
    • Mia R. Albalak
    • Avi Schroeder
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Synthetic biology encompasses engineering approaches to either redesign biological organisms with new molecular abilities or build up organism from the bottom to improve our understanding of life. Here, the authors summarize current approaches that can be applied for the synthetic engineering of viral replication cycles and discuss the potential DURC risk associated with such bottom-up approaches in infectious disease.

    • Oskar Staufer
    • Gösta Gantner
    • Joachim P. Spatz
    ReviewsOpen Access
    Nature Communications
    Volume: 13, P: 1-10