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Digital defocus aberration interference for automated optical microscopy

Digital defocus aberration interference, a physics-based defocus detection method, enables fast, reliable autofocus for thin and thick samples and improves digital refocusing for automated, high-throughput optical microscopy.

Haowen Zhou
Shi Zhao
Changhuei Yang
ResearchOpen Access24 Apr 2026
Nature Communications

P: 1-13
Analytic Fourier ptychotomography for aberration-free and high-resolution volumetric refractive index imaging

The authors propose Analytic Fourier Ptychotomography, for analytically reconstructing aberration-free, complex-valued 3D refractive index distributions without iterative optimization or axial scanning. The method has potential applications in biology, microbial ecology, and clinical science.

Zhenyu Dong
Haowen Zhou
Changhuei Yang
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 17, P: 1-12
POLCAM: instant molecular orientation microscopy for the life sciences

Combining localization and polarization microscopy can yield detailed insights into subcellular structures. POLCAM uses a polarization camera and wide-field microscopy for rapid measurement of super-resolution orientation imaging in live cells.

Ezra Bruggeman
Oumeng Zhang
Steven F. Lee
ResearchOpen Access07 Oct 2024
Nature Methods

Volume: 21, P: 1873-1883
Six-dimensional single-molecule imaging with isotropic resolution using a multi-view reflector microscope

A multi-view reflector microscope based on polarization modulation and pupil splitting enables single-molecule orientation-localization microscopy with precisions of 10.9 nm and 2.0°.

Oumeng Zhang
Zijian Guo
Matthew D. Lew
Research05 Dec 2022
Nature Photonics

Volume: 17, P: 179-186
Length-scale study in deep learning prediction for non-small cell lung cancer brain metastasis

Haowen Zhou
Siyu Lin
Changhuei Yang
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-13

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Digital defocus aberration interference for automated optical microscopy

Analytic Fourier ptychotomography for aberration-free and high-resolution volumetric refractive index imaging

POLCAM: instant molecular orientation microscopy for the life sciences

Six-dimensional single-molecule imaging with isotropic resolution using a multi-view reflector microscope

Length-scale study in deep learning prediction for non-small cell lung cancer brain metastasis

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