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Showing 1–5 of 5 results
Advanced filters: Author: Owen P. Janson Clear advanced filters

  • RNA-guided CRISPR-associated transposases (CAST) are natural systems with broad potential in biotechnology. Here, the authors report compact type V-K CAST discovered from genome-resolved metagenomics and demonstrate targeted integration of a large transgene to a safe-harbor site in the human genome.

    • Jason Liu
    • Daniela S. Aliaga Goltsman
    • Brian C. Thomas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. Here, the authors mine an extensive genome-resolved metagenomics database and identified uncharacterized families of RNA-guided, compact nucleases.

    • Daniela S. Aliaga Goltsman
    • Lisa M. Alexander
    • Christopher T. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Continued monitoring of SARS-CoV-2 at the population level is important for identifying at-risk groups. Here the authors analyse data from a serological surveillance platform in San Francisco and find considerable variation in infection and vaccination history by race/ethnicity and socioeconomic status.

    • Isobel Routledge
    • Saki Takahashi
    • Isabel Rodríguez-Barraquer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-7

  • Population-based surveys are the gold standard for estimating seroprevalence but are expensive and often only capture a small geographic area or window of time. This study describes a new platform, SCALE-IT, for serosurveillance based on algorithmic sampling of electronic health records, and uses it to estimate the seroprevalence of SARS-CoV-2 in San Francisco.

    • Isobel Routledge
    • Adrienne Epstein
    • Isabel Rodriguez-Barraquer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9