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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Michael Seldin and colleagues report a genome-wide association study and meta-analyses for primary biliary cirrhosis. They identify three loci newly associated with susceptibility to this autoimmune liver disease.

Xiangdong Liu
Pietro Invernizzi
Michael F Seldin
Research18 Jul 2010
Nature Genetics

Volume: 42, P: 658-660
GW190521 as a dynamical capture of two nonspinning black holes

Data from the gravitational wave event GW190521 can be explained by a semi-analytical model of two stellar-mass, nonspinning black holes on highly eccentric, hyperbolic orbits that undergo two close encounters before merging into an intermediate-mass black hole.

R. Gamba
M. Breschi
A. Nagar
Research17 Nov 2022
Nature Astronomy

Volume: 7, P: 11-17
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Clinical characteristics and factors predicting evolution of asymptomatic IgM monoclonal gammopathies and IgM-related disorders

E Morra
C Cesana
M Lazzarino
Research23 Aug 2004
Leukemia

Volume: 18, P: 1512-1517
Pathway-based analysis of primary biliary cirrhosis genome-wide association studies

S P Kar
M F Seldin
C I Amos
Research07 Feb 2013
Genes & Immunity

Volume: 14, P: 179-186
Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis

P Invernizzi
M Ransom
M F Seldin
Research10 May 2012
Genes & Immunity

Volume: 13, P: 461-468

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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

GW190521 as a dynamical capture of two nonspinning black holes

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Clinical characteristics and factors predicting evolution of asymptomatic IgM monoclonal gammopathies and IgM-related disorders

Pathway-based analysis of primary biliary cirrhosis genome-wide association studies

Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis

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