Biosynthesis of aromatic amines typically uses glutamic acid or glutamine as the nitrogen donor. Now, a biosynthetic pathway to aromatic amines has been reported that uses glycyl-tRNA as the nitrogen donor. The myosin-targeting ammosamide is made via a pathway that involves the post-translational modification of a tryptophan, which is added to the end of a peptide in a tryptophanyl-tRNA-dependent step.
- Page N. Daniels
- Hyunji Lee
- Wilfred A. van der Donk
